Plaque psoriasis is an autoimmune disorder that causes skin inflammation, causing rashes wi th itchy, scaly patches called plaques. These rashes can appear anywhere on one’s body but are most commonly observed around the knees, elbows, trunk, and scalp. As it is a chronic condition, there isn’t a permanent cure for plaque psoriasis. That said, certain biologic treatments like Tremfya can help control and relieve moderate to severe plaque psoriasis among adults.

Tremfya and its function
A prescription-based option, Tremfya (guselkumab) is the first-of-its-kind treatment method approved by the FDA for moderate to severe plaque psoriasis. Like other biologics, it is made from parts of living organisms with the help of advanced technology. With over 14 years of testing to support its results, the treatment is one of the most extensively researched prescription options to reduce symptoms and improve the appearance of the skin among those with plaque psoriasis.

Tremfya is a monoclonal antibody that selectively blocks the pro-inflammatory cytokine (protein) interleukin-23 (IL-23) in the body, which prompts the immune system into action. The blocking helps reduce the release of chemokines and cytokines to lower the inflammation associated with plaque psoriasis.

Efficacy and results
Clinical studies and research have shown the following effects of Tremfya on reducing plaque psoriasis:

– At least 7 out of 10 patients saw 90% clearer skin within the first 16 weeks of treatment.

– Overall, 9 out of 10 people who saw clearer skin at the 28-week mark continued to experience similar results even at 48 weeks.

– Nearly 7 out of 10 people who saw clearer skin at 16 weeks still experienced it after five years of treatment.

– Within 16 weeks, most study participants saw significant improvement in symptoms like itching, burning, pain, stinging, and skin tightness.

– In one of the studies, half the participants observed completely clear skin at 16 weeks.

– At the same 16-week mark, 4 out of 5 individuals with scalp psoriasis noted an almost clear or completely clear scalp with Tremfya.

Cost of Tremfya treatment
The overall cost of Tremfya may vary significantly, depending on the insurance coverage, geographical location, and the pharmacy one chooses. To improve access to this treatment, the manufacturer (Janssen Biotech) offers a program called Janssen CarePath, where eligible individuals can find financial support.

Additionally, the company runs an initiative called Tremfya withMe, which offers dedicated support and education about this line of treatment, its administration, and plaque psoriasis. Although this is not a medical advice group, it can help one better understand the condition and how it can be managed. Under this program, the company also offers Prescription and Cost Support in the form of a special program card, rebates, and more to help people reduce out-of-pocket expenses. This benefit is limited to those with private or commercial insurance. Others need to contact the company for more details and resources to make their treatment more affordable.